Anti IL-33R (ST2) antibody

$299.00
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Catalog
A20005
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Anti IL-33R (ST2) antibody

Clone HI05 Catalog#: A20005

Description: Anti-ST2 monoclonal antibody reacts with ST2, also known as IL-33 receptor (IL-33R) or Interleukin 1 receptor-like 1 IIL1RL1). ST2 is a member of the IL-1 receptor family. In the membrane-bound form, it consists of three extra-cellular immunoglobulin domains and an intracellular toll-interleukin-1 receptor domain. ST2 forms a dimer with IL-1R accessory protein in a ligand-dependent manner. The IL-33/ST2 interaction induces the production of TH2 cytokines. ST2 also has a soluble isoform lacking transmembrane and intracellular toll-interleukin-1 receptor domains. It is believed that the soluble form functions as a decoy receptor that can block membrane bound IL-33/ST2 interaction. ST2 is expressed by TH2 lymphocytes, mast cells, eosinophils, basophils, innate lymphocytes, smooth muscle cells, and endothelial cells and is involved in host defense, allergy, and inflammation.

 

Isotype:

Mouse IgG1

Species reactivity:

Mouse

Production:

Tissue culture

Purification:

Protein A/G

Applications:

WB, ELISA, FACS etc.

Immunogen: 

Human ST2

Storage: 

Store at +4°C short term (1-2 weeks). Store at -20°C long term.

Formulation:

PBS, pH 7.4, Filter sterilized. Endotoxin level tests less than 0.06 EU/ug.

Clonality:

Monoclonal

 

References

1. Masato Watanabe, et al. (2015). Soluble ST2 as a prognostic marker in community-acquired pneumonia. J Infect. 2015 May;70(5):474-82.

2. Zhou H, et al. (2015). Soluble ST2 may possess special superiority as a risk predictor in heart failure patients. Int J Cardiol. 2015;186:146-7.

3. Díaz-Jiménez D, et al. (2013). Soluble ST2 is a sensitive clinical marker of ulcerative colitis evolution. BMC Gastroenterol. 2016 Aug 26;16:103.

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