Anti IL-12 antibody

$599.00
In stock
Catalog
A20008
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Anti IL-12 antibody

Clone HI08  Catalog#: A20008

Description: Anti IL-12 monoclonal antibody reacts with human Interleukin 12 (IL-12). IL-12 is an interleukin that is naturally produced by dendritic cells,  macrophages, neutrophils, and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is composed of a bundle of four alpha helices. It is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). The active heterodimer (referred to as 'p70'), and a homodimer of p40 are formed following protein synthesis.

 

 

Isotype:

Mouse IgG1

Species reactivity:

Mouse

Production:

Tissue culture

Purification:

Protein A/G

Applications:

ELISA, IFA,WB, FACS etc.

Immunogen: 

Human IL-12

Storage: 

Store at +4°C short term (1-2 weeks). Store at -20°C long term.

Formulation:

PBS, pH 7.4, Filter sterilized. Endotoxin level tests less than 0.06 EU/ug.

Clonality:

Monoclonal

 

References

1. Feagan BG, et al. (2016). Ustekinumab as Induction and Maintenance Therapy for Crohn's Disease.N Engl J Med. 2016 Nov 17;375(20):1946-1960.

2. Harrison C. (2014). Patent watch: Stelara safe after IL-12 antibody dispute. Nat Rev Drug Discov.

3. Lasek W,et al. (2014). Interleukin 12: still a promising candidate for tumor immunotherapy?Cancer Immunol Immunother.

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