Anti-mouse CD276 (B7-H3)
Clone MJ18 Catalog#: A10115
Description: The MJ18 monoclonal antibody reacts with mouse CD276 also known as B7-H3. CD276 is a type I transmembrane protein and a member of the B7 family of co-stimulatory proteins. CD276 is expressed weakly on activated lymphocytes, macrophages, dendritic cells, nasal and airway epithelial cells, osteoblasts, and some tumor cell lines. A soluble form of CD276 is also secreted by monocytes, dendritic cells, and activated T cells. The biological role of CD276 is still under investigation however, recent studies suggest a negative regulatory role for CD276 in T cell responses. The MJ18 antibody has been shown to block CD276 when administered in vivo.
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Isotype: |
Rat IgG1 |
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Species reactivity: |
Mouse |
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Production: |
Tissue culture |
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Purification: |
Protein G |
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Recommended Isotype Control: |
Rat IgG1 Isotype control |
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Applications: |
in vivo B7-H3 blockade Flow Cytometry |
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Immunogen: |
CD276 / B7-H3 antibody was raised against mouse IgG2a Fc-CD276 (aa 1-242) |
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Storage: |
Store at +4°C short term (1-2 weeks). Store at -20°C long term. |
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Formulation: |
PBS, pH 7.4, Filter sterilized. Endotoxin level tests less than 0.06 EU/ug. |
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Clonality: |
Monoclonal |