Anti-Human DLL3 Monoclonal Antibody
Anti-Human DLL3 Monoclonal Antibody
Clone: Rovbio Catalog#: AB5747
Description:
Delta-like Ligand 3 (DLL3) is a single-pass transmembr protein that is attached to the cell surface and belongs to the Notch ligand family. The human DLL3 gene is located on chromosome 19q13, and its open reading frame length is approximately 1800 bp. The human DLL3 protein consists of 619 amino acids and has a complete structure that includes one DSL domain, one intracellular domain, and six epidermal growth factor-like domains. The N-terminal extracellular domain DSL gene sequence in the ligand family is highly conserved and is a functional domain required for binding to the Notch receptor. The DLL3 intracellular domain is shorter, and its function is unclear. Studies have found that DLL3 is highly expressed in SCLC and other neuroendocrine tumors but rarely expressed in normal tissues, which provides potential for targeted therapy. In recent years, more and more studies have suggested that DLL3 can bind to different Notch receptors and participate in complex tumor regulatory processes, which can exhibit both oncogenic and anti-oncogenic effects.
|
Reactivities: |
Human |
|
Target: |
DLL3 |
|
Clone: |
Rovbio |
|
Isotype: |
Human IgG1(E356D/M358L/KDel)-kappa |
|
Alternative Name: |
Anti-human DLL3 antigen; Anti-human Delta-like protein 3 |
|
Recommend Isotype Controls: |
|
|
Recommended Dilution Buffer: |
ABDB-1002 or PBS, pH 7.4,Contains no stabilizers or preservatives. |
|
Immunogen: |
N/A |
|
Formulation: |
PBS, pH 7.4,Contains no stabilizers or preservatives |
|
Endotoxin: |
<1EU/mg ,Determined by LAL gel clotting assay |
|
Purity: |
>95% Determined by SDS-PAGE |
|
Sterility: |
0.2 μM filtered |
|
Expression System: |
CHO |
|
Purification: |
Protein A |
|
Clonality: |
Monoclonal |
|
Storage: |
2 weeks, 2-8°C under sterile conditions after reconstitution. Avoid repeated freeze-thaw. -80°C for a long-term storage. |
|
Protocol Information: |
Since applications vary, each investigator should use the application references as a guide to help estimate the appropriate dose or concentration. The dose or concentration can be further optimized experimentally in a dose response or titration experiment. |
Intended for research use only. Not for human, therapeutic, or diagnostic applications.
The buyer cannot sell or otherwise transfer this product for Commercial Purposes without written approval of Humimmu LLC.
Copyright 2023. Humimmu LLC. All Rights Reserved
Please make sure that you follow below steps:
1/ Add your items of interest to the shopping cart by clicking Add to Cart.
2/ When you've finished shopping, click Check Out .You'll be asked to register if you are new to us.
3/ Fill in required shipping and payment information. We accept Credit Card and Paypal for online orders.
4/ Review your order, and then click Continue to Check Out.
5/ A confirmation email including tracking information of your order will be delivered to you through email within 24 hours. Please note that in case the item you are trying to purchase is not in stock, we will contact you directly to let you know the lead time.
If your company have credit reference sheet, please email (info@humimmu.com) to us, you are allowed to pay within 30 days after confirmation by our financial department.
If you don’t have credit reference sheet, please email (info@humimmu.com) us, and we will provide the Business Account Application Form for you.
Kindly remind that before applying for the payment terms, a full prepayment is required for the first time order from a valued new customer.