Anti Human Sialic acid binding globulin-like lectin-15 (hSiglec-15) Monoclonal Antibody
Anti Human Sialic acid binding globulin-like lectin-15 (hSiglec-15) Monoclonal Antibody
Clone HI526 Catalog#: A50526
Description: Siglec-15, a member of the Siglec family of sialic acid-binding Ig-like lectins, is a type I membrane protein primarily expressed in M2-type macrophages, myeloid-derived suppressor cells (MDSCs), dendritic cells, B cells, and osteoclasts. Studies have shown that for most PD-L1 negative tumor patients, siglec-15 is likely to be the main immune inhibitory factor. This protein is mutually exclusive with PD-L1, meaning that the expression of PD-L1 and Siglec-15 in tumor cells decreases as one increases. Siglec-15 can continuously inhibit T cell activity and exhibits the main characteristics of normalizing cancer immunotherapy. For those patients with psoriasis who are resistant to PD-1/PDL1 therapy, antibodies that block the interaction between Siglec-15 and CD33L3 may have immunotherapeutic effects.
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Isotype: |
Mouse IgG |
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Species reactivity: |
Mouse |
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Production: |
Tissue culture |
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Purification: |
Protein A/G |
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Applications: |
ELISA, IFA, FACS, WB, ICA |
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Immunogen: |
293T express recombination hSiglec-15 protein |
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Storage: |
Store at +4°C short term (1-2 weeks). Store at -20°C long term. |
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Formulation: |
PBS, pH 7.4, Filter sterilized. Endotoxin level tests less than 0.06 EU/ug. |
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Clonality: |
Monoclonal |
Reference:
- He F, Wang N, et al. (2021). High affinity monoclonal antibody targetingSiglec-15 for cancer immunotherapy. J Clin Transl Res. Nov 16;7(6):739-749eCollection 2021 Dec 28.
- Wang J, Sun J,et al.(2019).Siglec-15 as an immune suppressor andpotential target for normalization cancer immunotherapy. Nat MedApr;25(4):656-666
- Bornhofft KF, Goldammer T, et al. (2018). Siglecs: A journey through the evolution of sialic acid-binding immunoglobulin-type lectins. Dev CompImmunol.Sep;86:219-231.
Intended for research use only. Not for human, therapeutic, or diagnostic applications.
The buyer cannot sell or otherwise transfer this product for Commercial Purposes without written approval of Humimmu LLC.
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