Anti Human Neutrophil Gelatinase-Associated Apolipoprotein (hNGAL) Monoclonal Antibody
Anti Human Neutrophil Gelatinase-Associated Apolipoprotein (hNGAL) Monoclonal Antibody
Clone HI527 Catalog#: A50527
Description: Neutrophil gelatinase-associated lipocalin (NAGL), also known as lipocalin-2 (LCN2), is a small glycoprotein that belongs to the family of lipid-binding proteins. In addition to neutrophils, NAGL can be expressed in several other types of cells when they encounter damage. Although the specific biological function of NAGL is not yet clear, it is known that NAGL participates in the host's natural immunity by binding to siderophores produced by bacteria. NAGL exists in three forms in blood and urine: a 25kd monomer, a 45kd dimer linked by disulfide bonds, and a heterotrimer linked covalently with MMP-9. NAGL can serve as a biomarker for acute kidney injury (AKI) and chronic kidney disease (CKD), allowing early detection of structural kidney damage and prognosis of kidney diseases. In addition, similar to CRP and PCT, NAGL can also be used as a non-specific indicator of acute infection.
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Isotype: |
Mouse IgG |
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Species reactivity: |
Mouse |
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Production: |
Tissue culture |
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Purification: |
Protein A/G |
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Applications: |
ELISA, IFA, FACS, WB, ICA |
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Immunogen: |
293F express recombinant hNAGL protein |
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Storage: |
Store at +4°C short term (1-2 weeks). Store at -20°C long term. |
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Formulation: |
PBS, pH 7.4, Filter sterilized. Endotoxin level tests less than 0.06 EU/ug. |
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Clonality: |
Monoclonal |
Reference:
1. L Kjeldsen, AH Johnsen, et al.(1993). Ilation and primary structure of NGAL.a novel protein associated with human neutrophil gelatinase. J Biol Chem 1993 Ma15;268(14):10425 - 32.
2. Flo TH, KD Smith, ct al. (2004). Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron.Nature. Dec:432(7019):917 - 21.
3. Soni SS, Dinna Cruz, et al.(2010).NGAL: a biomarker of acute kidney injury and other systemic conditions. Int Urol Nephrol. Mar;42(1):141 - 50.
Intended for research use only. Not for human, therapeutic, or diagnostic applications.
The buyer cannot sell or otherwise transfer this product for Commercial Purposes without written approval of Humimmu LLC.
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