Broadly neutralizing antibodies against influenza A viruses, Fully human, 39.29, gedivumab, MHAA4549A
Clone 39.29 Catalog#: A90003
Description: 39.29 (gedivumab) is fully human neutralizing monoclonal antibody against influenza A. 39.29 is a neutralizing monoclonal antibody that recognizes the hemagglutinin (HA) glycoprotein of all 16 subtypes and neutralized both group 1 and group 2 influenza A viruses. 39.29 may be used for passive protection and to inform vaccine design because of its broad specificity and neutralization potency.
Isotype: |
IgG1 |
Species reactivity: |
Human |
Production: |
Tissue culture |
Purification: |
Protein A |
Applications: |
Neutralization assay, In vivo protection etc. |
Storage: |
Store at +4°C short term (1-2 weeks). Store at -20°C long term. |
Formulation: |
PBS, pH 7.4, Filter sterilized. Endotoxin level tests less than 0.06 EU/ug. |
Clonality: |
Monoclonal |
Reference:
- Nakamura G, et al. (2013). An in vivo human-plasmablast enrichment technique allows rapid identification of therapeutic influenza A antibodies.Cell Host Microbe. 2013 Jul 17;14(1):93-103.
- Deng R,et al. (2018). Pharmacokinetics of MHAA4549A, an Anti-Influenza A Monoclonal Antibody, in Healthy Subjects Challenged with Influenza A Virus in a Phase IIa Randomized Trial.Clin Pharmacokinet. 2018 Mar;57(3):367-377.
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