CD33 stable cell line, HEK293T, Red fluorescent protein (RFP)
CD33 stable cell line, HEK293T, Red fluorescent protein (RFP)
Catalog # C2001
For in vitro use only
Description
Stable, recombinant clonal HEK293T cell line constitutively expressing full length human CD33 protein. Surface expression of CD33 was confirmed by flow cytometry. This clonal cell line was selected for high level expression of CD33.
Background
CD33 is a 67 kDa type I transmembrane glycoprotein. It is expressed on monocytes, activated T cells, myeloid progenitors, mast cells and weakly on polymorphonuclear cells. CD33 can be stimulated by any molecule with sialic acid residues such as glycoproteins or glycolipids. Upon binding, the immunoreceptor tyrosine-based inhibition motif (ITIM) of CD33, present on the cytosolic portion the protein, is phosphorylated and acts as a docking site for Src homology (SH) 2 domain-containing proteins like SHP phosphatases. This results in a cascade that inhibits phagocytosis in the cell
Host Cell
HEK293T cell line
Contents
2 vial contains ~ 2 x 106 cells in freezing medium.
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