Anti-Human SOST Monoclonal Antibody
Anti-Human SOST Monoclonal Antibody
Clone: Rombio Catalog#: AB5846
Description:
Sclerostin is a negative regulator of bone formation, which is a secreted glycoprotein with cystine knot structure. It plays an important role in the regulation of bone remodeling. In the late 20th century, Van and Balemans found its disease gene Sost (Sclerosteosis, Sost) when they studied two genetic diseases with high bone mass in human beings.
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Reactivities: |
Human |
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Target: |
SOST |
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Clone: |
Rombio |
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Isotype: |
Human IgG2-kappa |
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Alternative Name: |
785A070802,AMG785,AMG-785,CDP-7851,CDP7851,romosozumab-aqqg,sclerostin Ab;sclerostin; SOST; VBCHsclerosteosis |
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Recommend Isotype Controls: |
Anti-HEL Human IgG2-Kappa Isotype control |
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Recommended Dilution Buffer: |
ABDB-1002 or PBS, pH 7.4,Contains no stabilizers or preservatives. |
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Immunogen: |
N/A |
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Formulation: |
PBS, pH 7.4,Contains no stabilizers or preservatives |
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Endotoxin: |
<1EU/mg ,Determined by LAL gel clotting assay |
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Purity: |
>95% Determined by SDS-PAGE |
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Sterility: |
0.2 μM filtered |
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Expression System: |
CHO |
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Purification: |
Protein A |
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Clonality: |
Monoclonal |
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Storage: |
2 weeks, 2-8°C under sterile conditions after reconstitution. Avoid repeated freeze-thaw. -80°C for a long-term storage. |
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Protocol Information: |
Since applications vary, each investigator should use the application references as a guide to help estimate the appropriate dose or concentration. The dose or concentration can be further optimized experimentally in a dose response or titration experiment. |
Intended for research use only. Not for human, therapeutic, or diagnostic applications.
The buyer cannot sell or otherwise transfer this product for Commercial Purposes without written approval of Humimmu LLC.
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