Anti-Human SLC34A2 Monoclonal Antibody
Anti-Human SLC34A2 Monoclonal Antibody
Clone: Upibio Catalog#: AB5861
Description:
NaPi-IIb is encoded by the gene SLC34A2, which was first isolated and cloned from human small intestine and lung cDNA libraries in 1999. Although SLC34A2 is expressed in various tissues of humans, its expression is highest in the lungs, small intestines, and kidneys. In the lungs, SLC34A2 is only expressed on the apical membrane of type II alveolar epithelial cells (ATII cells) and plays a key role in fetal lung development and embryonic development. ATII cells are multifunctional stem cells that can be transformed into NSCLC after exposure to exogenous or endogenous factors. Recent studies have found significant differences in SLC34A2 expression between surgical samples of NSCLC and normal tissues, and SLC34A2 is downregulated in lung adenocarcinoma cell line A549. Upregulation of SLC34A2 expression can significantly inhibit the viability and invasion of A549 cells in vitro. These results suggest that SLC34A2 may play an important role in the development of NSCLC.
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Reactivities: |
Human |
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Target: |
SLC34A2 |
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Clone: |
Upibio |
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Isotype: |
Human IgG1(K214R/E356D/M358L)-kappa |
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Alternative Name: |
XMT-1536;solute carrier family 34 sodium phosphate member 2, sodium/phosphate cotransporter 2B, NaPi2b, NaPi3b, NAPI-3B |
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Recommend Isotype Controls: |
Anti-HEL-Human IgG1(K214R/E356D/M358L)-kappa Isotype control |
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Recommended Dilution Buffer: |
ABDB-1002 or PBS, pH 7.4,Contains no stabilizers or preservatives. |
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Immunogen: |
N/A |
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Formulation: |
PBS, pH 7.4,Contains no stabilizers or preservatives |
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Endotoxin: |
<1EU/mg ,Determined by LAL gel clotting assay |
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Purity: |
>95% Determined by SDS-PAGE |
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Sterility: |
0.2 μM filtered |
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Expression System: |
CHO |
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Purification: |
Protein A |
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Clonality: |
Monoclonal |
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Storage: |
2 weeks, 2-8°C under sterile conditions after reconstitution. Avoid repeated freeze-thaw. -80°C for a long-term storage. |
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Protocol Information: |
Since applications vary, each investigator should use the application references as a guide to help estimate the appropriate dose or concentration. The dose or concentration can be further optimized experimentally in a dose response or titration experiment. |
Intended for research use only. Not for human, therapeutic, or diagnostic applications.
The buyer cannot sell or otherwise transfer this product for Commercial Purposes without written approval of Humimmu LLC.
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