Anti-Human PRLR Monoclonal Antibody
Anti-Human PRLR Monoclonal Antibody
Clone: Rolbio Catalog#: AB5871
Description:
Prolactin receptor (PRLR) is a cytokine receptor encoded by a gene located on chromosome 5p13-14, which can interact with prolactin as a transmembrane receptor. PRLR includes an extracellular domain that binds to prolactin, a transmembrane region and a cytoplasmic region. PRLR is widely expressed in mammary gland, placenta, kidney, liver and pancreas, and it can be activated by growth hormone (GH) and human placental lactogen (hPL) in addition to prolactin. Abnormalities of PRLR are closely related to the pathogenesis and prognosis of some tumors, especially breast cancer. Specific binding to PRLR can stimulate the growth of breast cancer cells, and some antagonists that can bind to PRLR but not form dimers can inhibit the growth of breast cancer cells. There are several isoforms of PRLR, among which soluble PRLR cannot transmit prolactin signals.
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Reactivities: |
Human |
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Target: |
PRLR |
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Clone: |
Rolbio |
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Isotype: |
Human IgG1(S239C)-kappa |
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Alternative Name: |
;PR-1594804,h16f;delta 4-delta 7/11 truncated prolactin receptor; delta 4-SF1b truncated prolactin receptor; hPRL receptor; hPRLrI; PRLR; PRL-R; Prolactin R; prolactin receptor delta 7/11; prolactin receptor; ProlactinR; secreted prolactin binding protein |
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Recommend Isotype Controls: |
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Recommended Dilution Buffer: |
ABDB-1002 or PBS, pH 7.4,Contains no stabilizers or preservatives. |
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Immunogen: |
N/A |
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Formulation: |
PBS, pH 7.4,Contains no stabilizers or preservatives |
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Endotoxin: |
<1EU/mg ,Determined by LAL gel clotting assay |
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Purity: |
>95% Determined by SDS-PAGE |
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Sterility: |
0.2 μM filtered |
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Expression System: |
CHO |
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Purification: |
Protein A |
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Clonality: |
Monoclonal |
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Storage: |
2 weeks, 2-8°C under sterile conditions after reconstitution. Avoid repeated freeze-thaw. -80°C for a long-term storage. |
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Protocol Information: |
Since applications vary, each investigator should use the application references as a guide to help estimate the appropriate dose or concentration. The dose or concentration can be further optimized experimentally in a dose response or titration experiment. |
Intended for research use only. Not for human, therapeutic, or diagnostic applications.
The buyer cannot sell or otherwise transfer this product for Commercial Purposes without written approval of Humimmu LLC.
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