Anti Human 217 Position Phosphorylated Tau Protein (p-Tau217) Monoclonal Antibody
Anti Human 217 Position Phosphorylated Tau Protein (p-Tau217) Monoclonal Antibody
Clone HI564 Catalog#: A50564
Description: Phosphorylation of Tau proteins is a normal regulatory mechanism, but in neurodegenerative diseases such as Alzheimer’s disease (AD), Tau can become abnormally hyperphosphorylated. This hyperphosphorylation leads to the dissociation of Tau from microtubules, the formation of toxic aggregates known as neurofibrillary tangles, and the disruption of neuronal function.
The phosphorylation of Tau at threonine 217 (T217) is one of the sites that are often modified in AD and other tauopathies. The phosphorylation at this site is thought to be particularly relevant to the pathogenesis of these diseases. Tau217 is considered a pathological phosphorylation site and has been found to correlate with the degree of cognitive impairment in AD patients.
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Isotype: |
Mouse IgG |
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Species reactivity: |
Mouse |
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Production: |
Tissue culture |
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Purification: |
Protein A/G |
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Applications: |
ELISA, WB, IFA, IHC, CLIA, LFA, IP |
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Immunogen: |
Recombinant human p-Tau217 protein |
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Storage: |
Store at +4°C short term (1-2 weeks). Store at -20°C long term. |
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Formulation: |
PBS, pH 7.4, Filter sterilized. Endotoxin level tests less than 0.06 EU/ug. |
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Clonality: |
Monoclonal |
Intended for research use only. Not for human, therapeutic, or diagnostic applications.
The buyer cannot sell or otherwise transfer this product for Commercial Purposes without written approval of Humimmu LLC.
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