Anti-Human CTLA4 Monoclonal Antibody
Anti-Human CTLA4 Monoclonal Antibody
Clone: Trebio Catalog#: MJ0001
Description:
Cytotoxic T-lymphocyte associated protein 4, (CTLA-4) also known as CD152 (cluster of differentiation 152), is a protein receptor that functions as an immune checkpoint and downregulates immune responses. Although CTLA-4 binds with B7 co-stimulatory receptors, it plays a negative role in the activation of T cells. CTLA-4s express and move to the cell membranes after T-cell activation, take over B7 from CD28, and suppress T-cell activity.
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Reactivities: |
Human |
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Target: |
CTLA-4 |
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Clone: |
Trebio |
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Isotype: |
Human IgG2(S378A) -kappa |
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Alternative Name: |
CP-675, 206, CP-675, CP-675206 clone 11.2.1, tremelimumab-actl;cytotoxic T-lymphocyte-associated protein 4, CD152 |
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Recommend Isotype Controls: |
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Recommend Controls CatNo.: |
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Recommended Dilution Buffer: |
ABDB-1002 or PBS, pH 7.4,Contains no stabilizers or preservatives. |
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Immunogen: |
N/A |
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Formulation: |
PBS, pH 7.4,Contains no stabilizers or preservatives |
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Endotoxin: |
<1EU/mg ,Determined by LAL gel clotting assay |
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Purity: |
>95% Determined by SDS-PAGE |
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Sterility: |
0.2 μM filtered |
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Expression System: |
CHO |
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Purification: |
Protein A |
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Storage: |
2 weeks, 2-8°C under sterile conditions after reconstitution. Avoid repeated freeze-thaw. -80°C for a long-term storage. |
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Protocol Information: |
Since applications vary, each investigator should use the application references as a guide to help estimate the appropriate dose or concentration. The dose or concentration can be further optimized experimentally in a dose response or titration experiment. |
Intended for research use only. Not for human, therapeutic, or diagnostic applications.
The buyer cannot sell or otherwise transfer this product for Commercial Purposes without written approval of Humimmu LLC.
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