Anti Human T cell immunoglobulin ITIM domain (hTIGIT) Monoclonal Antibody
Anti Human T cell immunoglobulin ITIM domain (hTIGIT) Monoclonal Antibody
Clone HI530 Catalog#: A50530
Description: TIGIT (T cell immunoglobulin and ITIM domain), also known as WUCAM, Vstm3, VSIG9, is a member of the PVR/Nectin family. It consists of an extracellular immunoglobulin variable domain (lgV) structure domain, a 1-type transmembrane domain, and an intracellular domain with classical immunoreceptor tyrosine inhibitory motifs (ITIMs) and immunoglobulin tyrosine tails (ITTs). TIGIT is expressed in lymphocytes, especially in effector and regulatory CD4+T cells, follicular helper CD4+T cells, effector CD8+T cells, and natural killer (NK) cells. So far, it has been found that TIGIT can interact with CD155, CD112, and CD113, among which the interaction between TIGIT-CD155 is the strongest. CD155 is mainly expressed on the surface of immune cells such as DC cells, T cells, B cells, macrophages, etc. In non-immune cells such as kidneys, lungs, and pancreases, there are also a small number of expressions. CD112 is widely expressed on the surface of hematopoietic system cells and non-hematopoietic system cells, but CD113 is only expressed on the surface of non-hematopoietic system cells. What's worth noting is that CD155 and CD112 are highly expressed on the surface of many malignant tumors such as colorectal cancer and melanoma.
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Isotype: |
Mouse IgG |
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Species reactivity: |
Mouse |
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Production: |
Tissue culture |
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Purification: |
Protein A/G |
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Applications: |
ELISA, IFA, FACS, WB, ICA |
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Immunogen: |
293T express recombination hTIGIT protein |
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Storage: |
Store at +4°C short term (1-2 weeks). Store at -20°C long term. |
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Formulation: |
PBS, pH 7.4, Filter sterilized. Endotoxin level tests less than 0.06 EU/ug. |
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Clonality: |
Monoclonal |
Reference:
- Chauvin JM,Zarour HM.(2020).TIGIT in cancer immunotherapy. J ImmunotherCancer.Sep;8(2):e000957.
- Harjunpa H,Guillerey C.(2020).TIGIT as an emerging immune checkpoint. ClinExp Immunol.May:200(2):108-119.
- Annese T, Tamma R, et al.(2022). Update in TIGIT Immune-Checkpoint Role inCancer.Front Oncol.May 17:12:871085.
Intended for research use only. Not for human, therapeutic, or diagnostic applications.
The buyer cannot sell or otherwise transfer this product for Commercial Purposes without written approval of Humimmu LLC.
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