Anti-Human HGF Monoclonal Antibody
Anti-Human HGF Monoclonal Antibody
Clone: Ficbio Catalog#: AB5814
Description:
Hepatocyte growth factor (HGF, also known as Scatter Factor) is among a group of factors possessing angiogenic ability. HGF was originally discovered as a fibroblast-derived cell motility factor for epithelial cells. It is synthesized by mesenchymal cells, fibroblasts, and smooth muscle cells. Active HGF is a heterodimer consists of a heavy chain (α chain, 62 kDa) and a light chain (β chain, 32-36 kDa), which are covalently linked by a disulfide bridge. HGF exerts its biological functions mediated by binding to the c-Met receptor. The HGF/c-Met signaling axis contributes in a paracrine manner to the development of epithelial organs, exerts regenerative effects on the epithelium, and promotes the regression of fibrosis in numerous organs. Additionally, the HGF/c-Met signaling pathway is correlated with the biology of cancer, neurons and immunity.
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Reactivities: |
Human |
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Target: |
HGF |
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Clone: |
Ficbio |
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Isotype: |
Human IgG1(K214R)-kappa |
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Alternative Name: |
AV-299,SCH 900105;deafness, autosomal recessive 39; DFNB39; EC 3.4.21; EC 3.4.21.7; fibroblast-derived tumor cytotoxic factor; F-TCF; hepatocyte growth factor (hepapoietin A; scatter factor); Hepatopoeitin-A; Hepatopoietin A; HGF; HGFB; HPTA; HPTAhepatocyte growth factor; lung fibroblast-derived mitogen; Scatter factor; SF; SFhepatopoeitin-A |
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Recommend Isotype Controls: |
Anti-HEL Human IgG1(K214R)-Kappa Isotype control |
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Recommended Dilution Buffer: |
ABDB-1002 or PBS, pH 7.4,Contains no stabilizers or preservatives. |
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Immunogen: |
N/A |
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Formulation: |
PBS, pH 7.4,Contains no stabilizers or preservatives |
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Endotoxin: |
<1EU/mg ,Determined by LAL gel clotting assay |
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Purity: |
>95% Determined by SDS-PAGE |
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Sterility: |
0.2 μM filtered |
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Expression System: |
CHO |
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Purification: |
Protein A |
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Clonality: |
Monoclonal |
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Storage: |
2 weeks, 2-8°C under sterile conditions after reconstitution. Avoid repeated freeze-thaw. -80°C for a long-term storage. |
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Protocol Information: |
Since applications vary, each investigator should use the application references as a guide to help estimate the appropriate dose or concentration. The dose or concentration can be further optimized experimentally in a dose response or titration experiment. |
Intended for research use only. Not for human, therapeutic, or diagnostic applications.
The buyer cannot sell or otherwise transfer this product for Commercial Purposes without written approval of Humimmu LLC.
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