Anti-Human CD159a Monoclonal Antibody
Anti-Human CD159a Monoclonal Antibody
Clone: Monbio Catalog#: AB5371
Description:
The natural killer (NK) cell receptor family 2 (NKG2) includes NKG2A/B/C/D/E/F. Among them, NKG2A is an inhibitory receptor in the NKG2 receptor family, also known as killer cell lectin like receptor C1 (KLRC1), CD159a, and NK cell receptor A, which are one of the transmembrane proteins preferentially expressed on the surface of NK cells. NKG2A is mainly expressed on the surface of NK cells and some T cells (CD8+T cells, Th2 cells, and NKT cells). On the surface of human immune cells, NKG2A-CD94, a heterodimer complex formed by the connection of NKG2A and CD94 molecules (NK cell surface facial mask protein) in the form of disulfide bonds, is recognized by the non classical histocompatibility complex I (MHC I) class molecule HLA-E on the target cells. This molecule is low expression under normal conditions, but on the surface of most tumor cells, the expression of HLA-E increases, thus inducing cascade inhibitory signals, inhibiting NK cytotoxicity and cytokine secretion. Certain viral infections, tumors, and immune diseases evade immune testing through this pathway.
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Reactivities: |
Human |
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Target: |
NKG2A |
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Clone: |
Monbio |
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Isotype: |
Human IgG4(S228P)-kappa |
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Alternative Name: |
IPH2201; IPH 2201; anti human NKG2A; anti human CD159Aa; anti human KLRC1; 1228763-95-8 |
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Recommend Isotype Controls: |
Anti-HEL Human IgG4 (S228P)-Kappa Isotype control |
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Recommended Dilution Buffer: |
ABDB-1002 or PBS, pH 7.4,Contains no stabilizers or preservatives. |
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Immunogen: |
N/A |
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Formulation: |
PBS, pH 7.4,Contains no stabilizers or preservatives |
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Endotoxin: |
<1EU/mg ,Determined by LAL gel clotting assay |
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Purity: |
>95% Determined by SDS-PAGE |
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Sterility: |
0.2 μM filtered |
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Expression System: |
CHO |
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Purification: |
Protein A |
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Clonality: |
Monoclonal |
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Storage: |
2 weeks, 2-8°C under sterile conditions after reconstitution. Avoid repeated freeze-thaw. -80°C for a long-term storage. |
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Protocol Information: |
Since applications vary, each investigator should use the application references as a guide to help estimate the appropriate dose or concentration. The dose or concentration can be further optimized experimentally in a dose response or titration experiment. |
Intended for research use only. Not for human, therapeutic, or diagnostic applications.
The buyer cannot sell or otherwise transfer this product for Commercial Purposes without written approval of Humimmu LLC.
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