Anti-Human B7-H3 Monoclonal Antibody
Anti-Human B7-H3 Monoclonal Antibody
Clone: Enobbio Catalog#: AB5312
Description:
B7-H3 is a member of the B7 ligand family (PD-L1 is also a member of this family), which is overexpressed in most cancer types but expressed at low levels in normal tissues. In benign tissues, B7-H3 has a significant inhibitory effect on adaptive immune responses, inhibiting T cell activation and expansion. In malignant tissues, B7-H3 inhibits tumor antigen-specific immune responses, resulting in a protumorigenic effect. B7-H3 also has non-immunogenic functions, such as promoting migration and invasion, angiogenesis, chemotherapy resistance, endothelial-to-mesenchymal transition, and affecting tumor cell metabolism. The expression of B7-H3 in tumors is associated with poor prognosis, and more and more people are paying attention to its potential value in tumor immunotherapy.
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Reactivities: |
Human |
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Target: |
B7H3 |
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Clone: |
Enobbio |
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Isotype: |
Human IgG1(K214R/L235V/ F243L/R292P/Y300L/P396L)-kappa |
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Alternative Name: |
MG-A271,MGA271；B7H3, B7-H3, B7-related protein 2, B7RP2, B7RP-2, B7 homolog 3, B7 homologue 3 |
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Recommend Isotype Controls: |
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Recommended Dilution Buffer: |
ABDB-1002 or PBS, pH 7.4,Contains no stabilizers or preservatives. |
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Immunogen: |
N/A |
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Formulation: |
PBS, pH 7.4,Contains no stabilizers or preservatives |
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Endotoxin: |
<1EU/mg ,Determined by LAL gel clotting assay |
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Purity: |
>95% Determined by SDS-PAGE |
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Sterility: |
0.2 μM filtered |
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Expression System: |
CHO |
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Purification: |
Protein A |
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Clonality: |
Monoclonal |
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Storage: |
2 weeks, 2-8°C under sterile conditions after reconstitution. Avoid repeated freeze-thaw. -80°C for a long-term storage. |
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Protocol Information: |
Since applications vary, each investigator should use the application references as a guide to help estimate the appropriate dose or concentration. The dose or concentration can be further optimized experimentally in a dose response or titration experiment. |
Intended for research use only. Not for human, therapeutic, or diagnostic applications.
The buyer cannot sell or otherwise transfer this product for Commercial Purposes without written approval of Humimmu LLC.
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