CD33 stable cell line, HEK293T, Red fluorescent protein (RFP)

$6,000.00
In stock
Catalog
C2001
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CD33 stable cell line, HEK293T, Red fluorescent protein (RFP)

Catalog # C2001

For in vitro use only

 

Description

Stable, recombinant clonal HEK293T cell line constitutively expressing full length human CD33 protein. Surface expression of CD33 was confirmed by flow cytometry. This clonal cell line was selected for high level expression of CD33.  

Background

CD33 is a 67 kDa type I transmembrane glycoprotein. It is expressed on monocytes, activated T cells, myeloid progenitors, mast cells and weakly on polymorphonuclear cells. CD33 can be stimulated by any molecule with sialic acid residues such as glycoproteins or glycolipids. Upon binding, the immunoreceptor tyrosine-based inhibition motif (ITIM) of CD33, present on the cytosolic portion the protein, is phosphorylated and acts as a docking site for Src homology (SH) 2 domain-containing proteins like SHP phosphatases. This results in a cascade that inhibits phagocytosis in the cell

Host Cell

HEK293T cell line 

Contents

2 vial contains ~ 2 x 106 cells in freezing medium.

 

Quality Assurance 

 

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