Anti-mouse CD8 antibody

$499.00
In stock
Catalog
A10009
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Anti-mouse CD8

Clone: 53-6.72 Catalog#: A10009

Descritpion: The 53-6.72 monoclonal antibody reacts with mouse CD8α. The CD8 antigen is a transmembrane glycoprotein that acts as a co-receptor for the T cell receptor (TCR). Like the TCR, CD8 binds to class I MHC molecules displayed by antigen presenting cells (APC). CD8 is primarily expressed on the surface of cytotoxic T cells, but can also be found on thymocytes, natural killer cells, and some dendritic cell subsets. CD8 most commonly exists as a heterodimer composed of one CD8α and one CD8β chain however, it can also exist as a homodimer composed of two CD8α chains. Both the CD8α and CD8β chains share significant homology to immunoglobulin variable light chains. The molecular weight of each CD8 chain is approximately 34 kDa. The 53-6.72 antibody exhibits depleting activity when used in vivo.

 

Isotype:

Rat IgG2a

Species reactivity:

Mouse

Production:

Tissue culture

Purification:

Protein G

Recommended Isotype Control:

Rat IgG2a Isotype control

Applications:

in vivo CD8+ T cell depletion

Immunofluorescence        

Flow cytometry

Western blot

Immunogen: 

Human PBMCs stimulated with PHA

Storage: 

Store at +4°C short term (1-2 weeks). Store at -20°C long term.

Formulation:

PBS, pH 7.4, Filter sterilized. Endotoxin level tests less than 0.06 EU/ug.

Clonality:

Monoclonal

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