Anti-mouse/human CD44

$199.00
In stock
Catalog
A10044
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Anti-mouse/human CD44

Clone IM7 Catalog#: A10044 

Description: The IM7 monoclonal antibody reacts with human and mouse CD44 also known as Hermes, HCAM, and Pgp-1. CD44 is an 80-95 kDa glycoprotein that is expressed on all leukocytes, endothelial cells, hepatocytes, and mesenchymal cells. As an adhesion molecule, CD44 participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, and hematopoiesis. CD44 is a receptor for hyaluronic acid and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Additionally, CD44 is involved in tumor metastasis and targeting of CD44 by antibodies has been shown to reduce the malignant activities of various neoplasms. Interestingly, high levels of the adhesion molecule CD44 on leukemic cells are essential to generate leukemia. The IM7 antibody has been shown to neutralize CD44 in vivo.

 

Isotype:

Rat IgG2b

Species reactivity:

Mouse/human

Production:

Tissue culture

Purification:

ProteinG

Recommended Isotype Control:

Rat IgG2b Isotype control

Applications:

in vivo CD44 neutralization

Immunogen: 

Dexamethasone-induced cells of the SJL mouse spontaneous myeloid leukemia M1

Storage: 

Store at +4°C short term (1-2 weeks). Store at -20°C long term.

Formulation:

PBS, pH 7.4, Filter sterilized. Endotoxin level tests less than 0.06 EU/ug.

Clonality:

Monoclonal

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