
Anti-mouse CTLA-4 (CD152)
Clone UC10-4F10-11Catalog#: A10038
Description: The UC10-4F10-11 monoclonal antibody reacts with mouse CTLA-4 (cytotoxic T lymphocyte antigen-4) also known as CD152. CTLA-4 is a 33 kDa cell surface receptor encoded by the Ctla4 gene that belongs to the CD28 family of the Ig superfamily. CTLA-4 is expressed on activated T and B lymphocytes. CTLA-4 is structurally similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to the B7 family members B7-1 (CD80) and B7-2 (CD86). Upon ligand binding, CTLA-4 negatively regulates cell-mediated immune responses. CTLA-4 plays roles in induction and/or maintenance of immunological tolerance, thymocyte development, and regulation of protective immunity. The critical role of CTLA-4 in immune down-regulation has been demonstrated in CTLA-4 deficient mice, which succumb at 3-5 weeks of age due to the development of a lymphoproliferative disease. CTLA-4 is among a group of inhibitory receptors being explored as cancer treatment targets through immune checkpoint blockade. The UC10-4F10-11 antibody has been shown to promote T cell co-stimulation by blocking CTLA-4 binding to the B7 co-receptors, allowing for CD28 binding.
Isotype: |
Armenian Hamster IgG |
Species reactivity: |
Mouse |
Production: |
Tissue culture |
Purification: |
Protein G |
Recommended Isotype Control: |
Polyclonal Armenian Hamster IgG |
Applications: |
in vivo CTLA-4 neutralization in vitro CTLA-4 neutralization Flow cytometry Western Blot |
Immunogen: |
Mouse CTLA-4 IgG2a Fusion |
Storage: |
Store at +4°C short term (1-2 weeks). Store at -20°C long term. |
Formulation: |
PBS, pH 7.4, Filter sterilized. Endotoxin level tests less than 0.06 EU/ug. |
Clonality: |
Monoclonal |