Anti-mouse CD25 (IL-2Rα) [7D4]
Clone: 7D4 Catalog#: A10018
Description: The 7D4 monoclonal antibody reacts with mouse IL-2Rα also known as CD25, Ly-43, p55, or Tac. IL-2Rα is the 55 kDa ligand-binding subunit of the interleukin 2 receptor alpha chain. IL-2Rα is expressed on activated mature T and B lymphocytes, thymocyte subsets, pre-B cells, and T regulatory cells. IL-2Rα has been shown to play roles in lymphocyte differentiation, activation, and proliferation. Alone, the IL-2Rα binds IL-2 with relatively low affinity however, when IL-2Rα associates with IL-2Rβ (CD122) and the common gamma chain (CD132) the complex binds IL-2 with high affinity. The 7D4 antibody recognizes a different epitope on CD25 than the PC-61.5.3 clone.
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Isotype: |
Rat IgM |
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Species reactivity: |
Mouse |
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Production: |
Tissue culture |
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Purification: |
T-Gel |
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Recommended Isotype Control: |
Rat IgM control |
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Applications: |
in vivo regulatory T cell inactivation |
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Immunogen: |
IL-2-dependent BALB/c mouse helper T-cell clone HT-2 |
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Storage: |
Store at +4°C short term (1-2 weeks). Store at -20°C long term. |
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Formulation: |
PBS, pH 7.4, Filter sterilized. Endotoxin level tests less than 0.06 EU/ug. |
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Clonality: |
Monoclonal |