Anti-mouse CD25 (IL-2Rα) [PC-61.5.3]

$199.00
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Catalog
A10017
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Anti-mouse CD25 (IL-2Rα) [PC-61.5.3]

Clone: PC-61.5.3 Catalog#: A10017

 

Description: The PC-61.5.3 monoclonal antibody reacts with mouse IL-2Rα also known as CD25, Ly-43, p55, or Tac. IL-2Rα is the 55 kDa ligand-binding subunit of the interleukin 2 receptor alpha chain. IL-2Rα is expressed on activated mature T and B lymphocytes, thymocyte subsets, pre-B cells, and T regulatory cells. IL-2Rα has been shown to play roles in lymphocyte differentiation, activation, and proliferation. Alone, the IL-2Rα binds IL-2 with relatively low affinity however, when IL-2Rα associates with IL-2Rβ (CD122) and the common gamma chain (CD132) the complex binds IL-2 with high affinity. The PC-61.5.3 antibody has been shown to inhibit the binding of IL-2 to both the low and high affinity IL-2 receptor forms. Additionally, the PC-61.5.3 antibody is commonly used to deplete CD4+FoxP3+ T regulatory cells in vivo.

 

Isotype:

Rat IgG1

Species reactivity:

Mouse

Production:

Tissue culture

Purification:

Protein A High Salt

Recommended Isotype Control:

Rat IgG1 Isotype control

Applications:

in vivo regulatory T cell depletion

Flow cytometry

Immunogen: 

murine IL-2R

Storage: 

Store at +4°C short term (1-2 weeks). Store at -20°C long term.

Formulation:

PBS, pH 7.4, Filter sterilized. Endotoxin level tests less than 0.06 EU/ug.

Clonality:

Monoclonal

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