Product Name:  

PLX4032<"/> PLX4032

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PLX4032

$112.00
In stock
Catalog
C10034
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PLX4032 (also known as Vemurafenib)  is a reversible, ATP-competitive inhibitor of B-Raf, a serine/threonine protein kinase with regulatory functions in mitogen-activated protein kinase (MAPK) signaling. In addition, PLX4032 inhibits Raf‑1 (also known as c-Raf), as well as several non-RAF kinases.

 

Interestingly, PLX4032 specifically blocks the MAPK pathway in cells expressing B-Raf-V600E, a B‑Raf mutant associated with different types of cancer. The V600E mutation in B-Raf leads to constitutive activation of MAPK signaling and increased cell proliferation. Inhibition of B-Raf‑V600E with PLX4032 induces cell cycle arrest and apoptosis. In B-Raf‑V600E models of cancer, PLX4032 induces partial or complete tumor regression.

 

Product Name:  

PLX4032

CAS #:

918504-65-1

Catalog#:

C10034

Molecular weight:

489.92

Formula:

C23H18ClF2N3O3S

Purity :

>98%

Description

PLX4032 (also known as Vemurafenib)  is a reversible, ATP-competitive inhibitor of B-Raf, a serine/threonine protein kinase with regulatory functions in mitogen-activated protein kinase (MAPK) signaling. In addition, PLX4032 inhibits Raf‑1 (also known as c-Raf), as well as several non-RAF kinases.

 

Interestingly, PLX4032 specifically blocks the MAPK pathway in cells expressing B-Raf-V600E, a B‑Raf mutant associated with different types of cancer. The V600E mutation in B-Raf leads to constitutive activation of MAPK signaling and increased cell proliferation. Inhibition of B-Raf‑V600E with PLX4032 induces cell cycle arrest and apoptosis. In B-Raf‑V600E models of cancer, PLX4032 induces partial or complete tumor regression.

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