Anti-human CD8 [OKT-8]

$599.00
In stock
Catalog
A10010
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Anti-human CD8 [OKT-8]

Clone: OKT-8 Catalog#: A10010

Description: The OKT-8 monoclonal antibody reacts with human CD8α. The CD8 antigen is a transmembrane glycoprotein that acts as a co-receptor for the T cell receptor (TCR). Like the TCR, CD8 binds to class I MHC molecules displayed by antigen presenting cells (APC). CD8 is primarily expressed on the surface of cytotoxic T cells, but can also be found on thymocytes, natural killer cells, and some dendritic cell subsets. CD8 most commonly exists as a heterodimer composed of one CD8α and one CD8β chain however, it can also exist as a homodimer composed of two CD8α chains. Both the CD8α and CD8β chains share significant homology to immunoglobulin variable light chains. The molecular weight of each CD8 chain is approximately 34 kDa. The OKT-8 antibody does not block the binding of the anti-human CD8α antibodies RPA-T8 and HIT8a.

 

Isotype:

Mouse IgG2a

Species reactivity:

Human

Production:

Tissue culture

Purification:

Protein G

Recommended Isotype Control:

Mouse IgG2a Isotype control

Applications:

in vivo CD8+ T cell depletion in humanized mice

Immunogen: 

human CD8a

Storage: 

Store at +4°C short term (1-2 weeks). Store at -20°C long term.

Formulation:

PBS, pH 7.4, Filter sterilized. Endotoxin level tests less than 0.06 EU/ug.

Clonality:

Monoclonal

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