Anti-CXCR4 antibody, Fully human
Anti-CXCR4 antibody, Fully human
Clone HI02 Catalog#: A20002
Description: Anti-CXCR4 Antibody is human antibody. CXCR-4 is an alpha-chemokine receptor specific for stromal-derived-factor-1 (SDF-1 also called CXCL12), a molecule endowed with potent chemotactic activity for lymphocytes. CXCR4 is one of several chemokine receptors that HIV can use to infect CD4+ T cells. HIV isolates that use CXCR4 are traditionally known as T-cell tropic isolates. Typically, these viruses are found late in infection. It is unclear as to whether the emergence of CXCR4-using HIV is a consequence or a cause of immunodeficiency.
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Isotype: |
Human IgG1, Kappa |
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Species reactivity: |
Human |
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Purification: |
Affinity chromatography |
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Recommended Isotype Control: |
Human IgG1 |
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Applications: |
ELISA, IFA, ADCC etc |
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Storage: |
Store at +4°C short term (1-2 weeks). Store at -20°C long term. |
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Formulation: |
PBS, pH 7.4, Filter sterilized. |
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Clonality: |
Monoclonal |
References:
1. Deng H, et al.(1996). Identification of a major co-receptor for primary isolates of HIV-1. Nature. 20;381(6584):661-6.
2. Zou Y R, et al.(1998). Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Nature, 1998, 393(6685):595-599.