Anti AAV1 antibody, Clone HI15
Clone HI15 Catalog#: A20015
Description: Anti AAV1 antibody reacts with AAV-1 only. Adeno-associated virus (AAV) is a small virus which infects humans and some other primate species. AAV is not currently known to cause disease. The virus causes a very mild immune response, lending further support to its apparent lack of pathogenicity. Gene therapy vectors using AAV can infect both dividing and quiescent cells and persist in an extrachromosomal state without integrating into the genome of the host cell, although in the native virus some integration of virally carried genes into the host genome does occur. AAV serotype 1 (AAV1) vector for the treatment of lipoprotein lipase deficiency.
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Isotype: |
Mouse IgG1 |
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Species reactivity: |
Mouse |
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Production: |
Tissue culture |
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Purification: |
Protein A/G |
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Applications: |
ELISA etc. |
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Immunogen: |
AAV1 virus |
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Storage: |
Store at +4°C short term (1-2 weeks). Store at -20°C long term. |
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Formulation: |
PBS, pH 7.4, Filter sterilized. Endotoxin level tests less than 0.06 EU/ug. |
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Clonality: |
Monoclonal |
References
1. Tseng YS, et al, (2016). Generation and characterization of anti-Adeno-associated virus serotype 8 (AAV8) and anti-AAV9 monoclonal antibodies. J Virol Methods. 2016 Oct;236:105-10.
2. Nakamura-Takahashi A, et al, (2016). Treatment of hypophosphatasia by muscle-directed expression of bone-targeted alkaline phosphatase via self-complementary AAV8 vector. Mol Ther Methods Clin Dev. 2016 Feb 3;3:15059.
