Anti-CCR4 antibody, Fully Human

$399.00
In stock
Catalog
A20001
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Anti-CCR4 antibody, Fully human

Clone HI01 Catalog#: A20001

 

Description: Fully human anti-CCR4 antibody. C-C chemokine receptor type 4 (CCR4) is a protein that in humans is encoded by the CCR4 gene. CCR4 has also recently been designated CD194 (cluster of differentiation 194).The protein encoded by this gene belongs to the G protein-coupled receptor family. CCR4 is a chemokine receptor and is preferentially expressed on type 2 helper T (Th2-type) cells. In contrast to other chemokine receptors, the expression of CCR4 and CCR8 on Th2 cells is transiently increased following TCR and CD28 engagement. Moreover, activated Th1 cells up-regulate CCR4 expression and functional responsiveness to thymus- and activation-regulated chemokine.

 

Isotype:

Human IgG1, Kappa

Species reactivity:

Human

Purification:

Affinity chromatography

Recommended Isotype Control:

Human IgG1

Applications:

ELISA, IFA, ADCC etc

Storage: 

Store at +4°C short term (1-2 weeks). Store at -20°C long term.

Formulation:

PBS, pH 7.4, Filter sterilized.

Clonality:

Monoclonal

 

References:

1. Lloyd C M, et al.(2000). CC chemokine receptor (CCR) 3/eotaxin is followed by CCR4/monocyte-derived chemokine in mediating pulmonary T helper lymphocyte type 2 recruitment after serial antigen challenge in vivo. The Journal of experimental medicine. 191(2): 265-274.

2. Ishida T, et al.(2003). Clinical Significance of CCR4 Expression in Adult T-Cell Leukemia/Lymphoma Its Close Association with Skin Involvement and Unfavorable Outcome. Clinical Cancer Research. 9(10): 3625-3634.

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